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Annons

Den allmänna snacktråden, 2008


Neosus

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Annons
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De måste måste måste måste måste komma till Sverige! 😉

Jag läste på Pitchfork att Of Montreal skulle till Europa igen men inget Sverige den här gången. Nästa gång ska jag nog försöka gå.

Jo, of Montreal är ju en sak, men liksom hela original-e6-gänget...

Jag har precis över 5 dygn.

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Dags att dra igång kvällspasset, ska vara klar med utkast nr. 2 av examensarbetet till imorgon!

Kollade förresten hur långa de brukar vara... min är typ hälften så lång jämfört med resten 😉 . Fail.

Vad handlar det om?

Du kan få mitt abstract, varsågod 😉

(det är den enda delen som är skriven på engelska, kändes ganska ovant att skriva det och grammatiska påpekanden uppskattas!)

Rheumatoid arthritis (RA) is an autoimmune disease, where joints are attacked by the own immune system, which leads to chronic inflammation and destruction of bone and cartilage. Inflammation is a complex mechanism, controlled by many different substances. One of those are adenosine, which has an anti-inflammatory role. In this project, three polymorphisms in different genes involved in synthesis and signaling through adenosine, were genotyped for 188 patients with RA and 362 controls without RA. The results shows that for the polymorphism in A2a, a gene for an adenosine receptor, there is no significant differences in genotype distribution between the groups. There were however some differences in the general sensation of pain and well-being reported by the patients. For the polymorphism in NT5E, which results in a nucleotidase for extracellular adenosine synthesis, there were differences in both genotype distribution between the groups, and in the progression of the disease. The NT5E-AA genotype seems to increase inflammation and decrease the number of tender joints. In the case of the polymorphism in ADA, which codes for adenosine deaminase, the number of patients with the mutant allele was too small for any conclusions to be made. In addition to this, comparisons in alcohol consumption and the polymorphisms were performed, but the study was too small to generate any viable results. The project shows that the polymorphism in NT5E, whose functional consequences are unknown, might have an effect on the extracellular adenosin synthesis. Further studies are required for any certain conclusions to be made.
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